In the sub-zero temperatures of the Arctic stands The Amoninsula Research Facility, a bunker housing the world's top scientists dedicated to studying and containing “Hazards”, anomalies which defy the laws of physics, as well as common sense. After a streak of unlucky incidents, Estelle Mcclendon finds herself in an encounter with a Hazard, becoming a “Host” for “Miasma”, an amorphous floating cloud that seeks to subsume living organisms. Miasma will gradually spread through the body, deteriorating bone and tissues alike until the weakened internal organs can no longer sustain the human functions necessary for life. With no known cure for a Host infected by Miasma, Estelle spends the remainder of her days exchanging messages with her closest coworker, Abbi. Together, they do their best to feel intimacy by being perverts together while staring the looming, macabre regression toward death straight in the eye.