16 students wake up in a strange, seemingly abandoned ancient laboratory. A strange haze appears to fill the entire building, but slowly and surely it becomes unnoticeable. These 16 students have all committed a crime some time in their life and have been on the run from it for a while. Not like they'll let their fellow students know it. Soon enough, they find themselves thrown into a killing game in this strange laboratory and one by one start to get punished for their crimes. Danganronpa: Antebellum is modeled after Danganronpa with RPG and puzzle solving elements both features in the trials.