Sanguine Rose begins with Roman and his fellow mercenaries trapped in the snowy village Whitewood with their recently abducted prisoner: High General Carmen Valentine. While Roman and his company deliberate on their next course of action, Carmen is planning to use every means at her disposal to escape. Not only is Carmen a skilled soldier, but also a terrifyingly charismatic hedonist. Upon waking captured by your party she will immediately attempt to escape by playing head games with Roman and the other mercenaries. Roman, meanwhile, will respond almost entirely to player direction, with a wide array of choices available to make. Will you attempt to seduce Carmen, or will you succumb to her will? Can you keep her from escaping while she turns your team against you, or you against them?